The missile strike was the latest in a series of attacks that have caused civilian casualties, despite continuing cease-fire talks.

Dozens of foreign governments were trying to appeal to the president to have steep tariffs rolled back, but the president and his advisers have indicated negotiations could be difficult.

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U.S. markets were set to open sharply lower as well. President Trump said on Sunday that he would not back off his trade war, reinforcing fears of a global economic downturn.